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The impacts of infrastructure development on ecosystems and biodiversity are vividly evident today. Roads represent the first tendrils of human expansion, driving deforestation and degradation, opening thousands of hectares of previously intact habitat to land-use change, agricultural expansion, human settlement, wildlife exploitation and trade, and increasing zoonotic disease risk. In this context, 24 public and private sector organizations joined together in 2020 to create the Infrastructure and Nature Coalition to organize a series of webinar discussions with the aim to bolster countries’ efforts to meet previous targets and make stronger commitments for mitigating climate change and biodiversity loss during the 2021 “Super Year” for nature, including meetings of the IUCN World Conservation Congress, the Convention on Biological Diversity’s (CBD) 15th Conference of the Parties (COP 15), and the Framework Convention on Climate Change’s (UNFCCC) 26th Conference of the Parties (COP 26). The interests of SaveGREEN were advocated by representatives of WWF-CEE.